Blisters on the leg can appear for many reasons, and understanding the cause helps guide proper care. Friction is one of the most common triggers, especially when skin rubs against a brace, tight clothing, or footwear that reaches the lower leg. Heat and moisture can also weaken the skin’s surface, making blisters more likely. Some blisters develop from contact reactions, such as poison ivy or irritants applied to the skin. Viral or bacterial infections may lead to fluid-filled lesions as well. Circulatory problems, including arterial or venous disease, can cause fragile skin that blisters easily, sometimes even without injury. Certain medical conditions, like edema, eczema, or autoimmune disorders, can also contribute. Blisters can open the door to infection, especially for people with underlying health issues. If you have such skin eruptions, it is suggested that you see a wound care specialist for an evaluation and appropriate treatment.

Why Blisters Can Be Risky for Leg and Foot Health
Blisters are small pockets of fluid that form beneath the skin, often as a result of friction, pressure, or burns. On the feet, ankles, and legs, they are particularly common because these areas endure daily stress from walking, running, and wearing shoes. While many blisters are minor, they can become serious if not treated correctly, especially in individuals with diabetes or poor circulation.
Friction is the most common cause of blisters. Shoes that are too tight, too loose, or not properly cushioned may rub against the heel, toes, or sides of the foot, leading to painful fluid-filled bubbles. Activities such as hiking, sports, or even long periods of standing can also trigger blisters, especially when combined with moisture from sweat.
Other blisters may form from burns, allergic reactions, or underlying medical conditions. On the lower extremities, blisters that break open expose the skin to bacteria, increasing the risk of infection and complicating the healing process. If a blister appears on the ankle, heel, or shin, it may interfere with walking and daily mobility.
Proper care begins with protecting the blister. Keeping the area clean, covered, and free from further friction supports healing. However, large, painful, or recurrent blisters often require professional evaluation. For patients with compromised circulation or nerve damage, even a small blister can turn into a much larger problem if ignored.
A wound care specialist can determine the cause, provide safe drainage if needed, and apply advanced dressings to promote recovery. They can also recommend changes in footwear, activity, or skin protection strategies to prevent future blisters.
If you have developed a blister on your foot, ankle, or leg that is not healing or is becoming more painful, make an appointment with us as soon as possible.